Nanopareil produces cutting-edge separation media composed of functionalized nanofibers. The product is manufactured from a randomly overlaidmat of electrospun nanofibers, which provide  a unique separation medium capable of both size-based as well as adsorptive separation mechanisms.   The highly advanced and proprietary formulation provides the opportunity to greatly enhance process efficiencies and economics in the antibody, vaccine, and blood product purification markets.

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From Development to Manufacturing

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Benefits of Nanopareil

Purification modules produced by Nanopareil offer major advantages over commercial microfiber separation media and packed bed adsorption resins. Specifically, our nanofiber products provide an enormous amount of specific surface area along with a controlled porosity and offers modular, off-the- shelf installation into existing manufacturing processes.

These three combined features allow for major production advantages, including:

  • Faster throughput, lower operating pressure
  • Higher adsorptive capacity
  • Less water consumption, less waste generation
  • Greatly improved manufacturing simplicity and reproducibility.

Our Story

Nanofiber Separations, LLC was born out of a project sponsored by the National Science Foundation (NSF) that began in 2006. In July of 2015 Nanofiber Separations, LLC officially changed its name to Nanopareil, LLC. During this five-year project, the company co-founders, Dr. Todd Menkhaus and Dr. Hao Fong, determined that a commercially available nanofiber product would be a significant improvement over existing adsorption and size-based separation media in several, high-value market segments. With this major unmet need for advanced purification devices confirmed in the marketplace, Nanopareil was organized as a limited liability company under the laws of the State of South Dakota in October, 2011. In February 2014, Nanopareil was awarded a National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase II Grant and in April of 2014, Nanofiber Separations received statewide recognition by winning the South Dakota Governor’s Giant Vision Business Plan Competition.


D. Craig Arnold

President & Chief Executive Officer

Craig Arnold’s leadership experience spans more than 30 years, including technology start-ups, biotechnology and biofuels, as well as leadership positions in philanthropy, computer technology and aerospace industries. Prior to joining Nanopareil, Arnold was President & CEO of Permara, LLC, a South Dakota biotech start-up that commercialized a novel renewable antimicrobial technology. As CEO of Plymouth Energy, Arnold led the $100M debt/equity financing, construction, and production start-up of a Midwest based 50 million gallon a year (MGY) biofuels plant. Craig was a Director at the Bill and Melinda Gates Foundation, where he was responsible for the Foundation’s access to a technology program that was expanded worldwide. Arnold held leadership roles at Northrop-Grumman and Rockwell International (Boeing) on the B2 Stealth Bomber and B1B Lancer aircraft programs respectively. Mr. Arnold holds a commercial pilot’s license and is a multi-engine and instrument instructor pilot.

Todd J Menkhaus, PhD


Dr. Todd Menkhaus is a co-founder of Nanopareil, LLC and a Managing Member of the Company. He leads the separations analysis and characterization aspects of the company’s technology portfolio. Due to his experience in the water treatment and biopharmaceutical areas, he is also the primary point of contact for industrial partners working with Nanopareil. Dr. Menkhaus has a Ph.D. in Chemical Engineering from Iowa State University and has over 20 years of experience working in the water treatment and biopharmaceutical industries, including leading process development and cGMP manufacturing divisions within two different pharmaceutical companies (Regeneron Pharmaceuticals and XOMA). He has published more than 30 peer-reviewed journal articles pertaining to separations and has made over 150 invited presentations to a diverse set of national and international audiences. His research activities have enjoyed the sponsorship of the NSF, USDA, DOE, State of South Dakota, and several industrial partners with over $2.5 million in grant expenditures as the Principal Investigator, and over $6.5 Million as Co-Principal Investigator.


Published Books

Menkhaus, Todd, J.; Zhang, Lifeng; Fong, Hao (2010).  Nova Science Publishers


Published Articles

Menkhaus, Todd J.; Varadaraju, Hemanthram; Zhang, Lifeng; Schneiderman, Steven; Bjustrom, Stephany; Liu, Li; Fong, Hao (2010). Electrospun nanofiber membranes surface functionalized with 3-dimensional nanolayers as an innovative adsorption medium with ultra-high capacity and throughput.

autam, A.K., Lai, C., Fong, H., Menkhaus, T.J.  Electrospun Polyimide Nanofiber Membranes for High Flux and Low Fouling Microfiltration Applications.

Schneiderman, Steven; Varadaraju, Hemanthram; Zhang, Lifeng; Fong, Hao; Menkhaus, Todd J. (2011). Mathematical model using non-uniform flow distribution for dynamic protein breakthrough with membrane adsorption media.

Schneiderman, Steven; Zhang, Lifeng; Fong, Hao; Menkhaus, Todd J. (2011). Surface-functionalized electrospun carbon nanofiber mats as an innovative type of protein adsorption/purification medium with high capacity and high throughput.

Varadaraju, Hemanthram; Schneiderman, Steven; Zhang, Lifeng; Fong, Hao; Menkhaus, Todd J. (2011). Process and Economic Evaluation for Monoclonal Antibody Purification Using a Membrane-Only Process.

Zhang, Lifeng; Luo, Jie; Menkhaus, Todd J.; Varadaraju, Hemanthram; Sun, Yuyu; Fong, Hao (2011). Antimicrobial nano-fibrous membranes developed from electrospun polyacrylonitrile nanofibers.

Zhou, Zhengping; Liu, Kunming; Lai, Chuilin; Zhang, Lifeng; Li, Juanhua; Hou, Haoqing; Reneker, Darrell H.; Fong, Hao (2010). Graphitic carbon nanofibers developed from bundles of aligned electrospun polyacrylonitrile nanofibers containing phosphoric acid.

Zhang, L.; Menkhaus, T.J.; and Fong, H.  Fabrication and Bioseparation Studies of Adsorptive Nanofelts Made from Electrospun Cellulose Acetate Nanofibers.

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