Nanopareil produces cutting-edge separation media composed of functionalized nanofibers. The product is manufactured from a randomly overlaid mat of electrospun nanofibers, which provide a unique separation medium capable of both size-based as well as adsorptive separation mechanisms. The highly advanced and proprietary formulation provides the opportunity to greatly enhance process efficiencies and economics in the antibody, vaccine, and blood product purification markets.
What is Nanopareil
Purification modules produced by Nanopareil offer major advantages over commercial microfiber separation media and packed bed adsorption resins. Specifically, our nanofiber products provide an enormous amount of specific surface area along with a controlled porosity and offers modular, off-the- shelf installation into existing manufacturing processes.
These three combined features allow for major production advantages, including:
- Faster throughput, lower operating pressure
- Higher adsorptive capacity
- Less water consumption, less waste generation
- Greatly improved manufacturing simplicity and reproducibility.
Benefits of Nanopareil
Over $110 million annual savings for a single biopharmaceutical product
Over 30% reduction in overall operating costs per kg of product
Over 10-times faster throughput – shorter processing times, reduced labor, more efficient use of limited manufacturing space
Over 10-times higher capacity – lower materials requirements
Over 5-times less water consumption – reduced loads on purified water systems
Over 5-times less waste generation – more environmentally friendly production processes and lower waste disposal costs
Off-the-shelf installation into the manufacturing processNo capital investment required for switching from existing packed bed operations to nanofiber based adsorption media
Net $1.00/gallon through recovery of high-value co-products from advanced bio-fuels
Capturing and purifying fermentation inhibitory compounds
These compounds have large and growing chemical market demands
100 Million Gallon Plant would recover 60,000 tons/year
Removal of inhibitory compounds prior to fermentation
Incorporating nanofiber separation products into advanced biofuels process has the potential to reduce costs by over $1/gallon of produced fuel.
Water Purification Benefits
Rapid deployment, Low Energy, High-efficiency water purification for military & disaster uses; Better than Reverse Osmosis
Utilizing compact, low pressure, low energy, and high flow nanofibers separation to:
- Remove any or all water impurities, including
- Suspended solids, heavy metals, salts
- Microbial contaminants, viruses
- Targeted chemical or biological species
- Reduced operating footprint by over 10 fold
- Reduced processing time by over 10 fold
Nanofiber Separations, LLC was born out of a project sponsored by the National Science Foundation (NSF) that began in 2006. In July of 2015 Nanofiber Separations, LLC officially changed its name to Nanopareil, LLC. During this five-year project, the company co-founders, Dr. Todd Menkhaus and Dr. Hao Fong, determined that a commercially available nanofiber product would be a significant improvement over existing adsorption and size-based separation media in several, high-value market segments. With this major unmet need for advanced purification devices confirmed in the marketplace, Nanopareil was organized as a limited liability company under the laws of the State of South Dakota in October, 2011. In February 2014, Nanopareil was awarded a National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase II Grant and in April of 2014, Nanofiber Separations received statewide recognition by winning the South Dakota Governor’s Giant Vision Business Plan Competition.
Meet Our Team
D. Craig Arnold
Craig Arnold’s leadership experience spans more than 30 years, including technology start-ups, biotechnology and biofuels, as well as leadership positions in philanthropy, computer technology and aerospace industries. Prior to joining Nanopareil, Arnold was President & CEO of Permara, LLC, a South Dakota biotech start-up that commercialized a novel renewable antimicrobial technology. As CEO of Plymouth Energy, Arnold led the $100M debt/equity financing, construction, and production start-up of a Midwest based 50 million gallon a year (MGY) biofuels plant. Craig was a Director at the Bill and Melinda Gates Foundation, where he was responsible for the Foundation’s access to a technology program that was expanded worldwide. Arnold held leadership roles at Northrop-Grumman and Rockwell International (Boeing) on the B2 Stealth Bomber and B1B Lancer aircraft programs respectively. Mr. Arnold holds a commercial pilot’s license and is a multi-engine and instrument instructor pilot.
Todd J Menkhaus, PhD
Dr. Todd Menkhaus is a co-founder of Nanopareil, LLC and a Managing Member of the Company. He leads the separations analysis and characterization aspects of the company’s technology portfolio. Due to his experience in the water treatment and biopharmaceutical areas, he is also the primary point of contact for industrial partners working with Nanopareil. Dr. Menkhaus has a Ph.D. in Chemical Engineering from Iowa State University and has over 20 years of experience working in the water treatment and biopharmaceutical industries, including leading process development and cGMP manufacturing divisions within two different pharmaceutical companies (Regeneron Pharmaceuticals and XOMA). He has published more than 30 peer-reviewed journal articles pertaining to separations and has made over 150 invited presentations to a diverse set of national and international audiences. His research activities have enjoyed the sponsorship of the NSF, USDA, DOE, State of South Dakota, and several industrial partners with over $2.5 million in grant expenditures as the Principal Investigator, and over $6.5 Million as Co-Principal Investigator.
Hao Fong, PhD
Dr. Hao Fong is a co-founder of Nanopareil, LLC and a Managing Member of the Company. He leads the electrospun nanofiber product manufacturing & development efforts for the company. Dr. Fong is one of the pioneers and renowned scientists worldwide in “Electrospinning and Nanofibers”, as evidenced by the number of peer-reviewed journal articles (≈100), books and/or book chapters (≈12), and citations of his publications (≈8,000). His highest degree is a Ph.D. earned in 1999 from the Department of Polymer Science at the University of Akron, and his Ph.D. advisor is Dr. Darrell H. Reneker who re-invented electrospinning in the early 1990’s. Dr. Fong has established a vigorous research program on “Electrospun Polymeric, Ceramic, Metallic, Carbonaceous Nanofibers and Their Applications” at SDSM&T, which has been supported by the NSF, NIH, US Army, US Air Force, DOE, NASA, and the State of South Dakota with the total funding over $4 Million as Principal Investigator.
Mr. Steve Schneiderman
Mr. Steve Schneiderman has extensive experience working on nanofiber fabrication, characterization, and bioseparations evaluations. Steve is the lead author of three published articles describing the first generation nanofiber products.
Dr. Yong Zhao
Dr. Yong Zhao has post-doctoral scientist with expertise in the electrospinning processes. Zhao has developed multiple trade-secret innovations.
Dr. Jennifer Leberknight, PE
Dr. Jennifer Leberknight, PE has extensive expertise in bioseparations and her primary responsibilities include the design and execution of laboratory experiments to optimize nanofiber functionalization. Dr. Leberknight will also coordinate multiple engineering design projects and product development and testing.
Dr. Nyle E. Hedin
Dr. Nyle E. Hedin oversees all development projects and coordinates activities between the electrospinning and separations groups. Dr. Hedin has extensive experience with preparation, characterization, and evaluation of electrospun nanofibers.
CHEMICAL COMMUNICATIONS. 46 (21), 3720-3722
Menkhaus, Todd J.; Varadaraju, Hemanthram; Zhang, Lifeng; Schneiderman, Steven; Bjustrom, Stephany; Liu, Li; Fong, Hao (2010). Electrospun nanofiber membranes surface functionalized with 3-dimensional nanolayers as an innovative adsorption medium with ultra-high capacity and throughput.
JOURNAL OF MEMBRANE SCIENCE, IN-PRESS (2014)
autam, A.K., Lai, C., Fong, H., Menkhaus, T.J. Electrospun Polyimide Nanofiber Membranes for High Flux and Low Fouling Microfiltration Applications.
JOURNAL OF CHROMATOGRAPHY A. 1218 (51), 9121-9127
Schneiderman, Steven; Varadaraju, Hemanthram; Zhang, Lifeng; Fong, Hao; Menkhaus, Todd J. (2011). Mathematical model using non-uniform flow distribution for dynamic protein breakthrough with membrane adsorption media.
JOURNAL OF CHROMATOGRAPHY A. 1218 (50), 8989-8995
Schneiderman, Steven; Zhang, Lifeng; Fong, Hao; Menkhaus, Todd J. (2011). Surface-functionalized electrospun carbon nanofiber mats as an innovative type of protein adsorption/purification medium with high capacity and high throughput.
BIOTECHNOLOGY PROGRESS. 27 (5), 1297-1305
Varadaraju, Hemanthram; Schneiderman, Steven; Zhang, Lifeng; Fong, Hao; Menkhaus, Todd J. (2011). Process and Economic Evaluation for Monoclonal Antibody Purification Using a Membrane-Only Process.
JOURNAL OF MEMBRANE SCIENCE. 369 (1-2), 499-505
Zhang, Lifeng; Luo, Jie; Menkhaus, Todd J.; Varadaraju, Hemanthram; Sun, Yuyu; Fong, Hao (2011). Antimicrobial nano-fibrous membranes developed from electrospun polyacrylonitrile nanofibers.
POLYMER. 51 (11), 2360-2367
Zhou, Zhengping; Liu, Kunming; Lai, Chuilin; Zhang, Lifeng; Li, Juanhua; Hou, Haoqing; Reneker, Darrell H.; Fong, Hao (2010). Graphitic carbon nanofibers developed from bundles of aligned electrospun polyacrylonitrile nanofibers containing phosphoric acid.
JOURNAL OF MEMBRANE SCIENCE, 319, 176-184 (2008)
Zhang, L.; Menkhaus, T.J.; and Fong, H. Fabrication and Bioseparation Studies of Adsorptive Nanofelts Made from Electrospun Cellulose Acetate Nanofibers.